To date, a plethora of biomaterials as wound dressings for different clinical treatment protocols have been developed, which may be composed of synthetic or natural materials, or may be a hybrid of the two. In this chapter, we describe advanced hydrogels for wound healing and enhanced skin repair. In view of this, hydrogels have gradually become ideal wound dressings in recent years and show good prospects in the treatment of burns and other skin injuries. In addition, compared with traditional dressings, the non-adhesive nature of the hydrogel avoids secondary damage, and its 3D network structure is conducive to absorbing wound exudate while maintaining an ideal moist environment. More and more research results show that hydrogels have the ability to deliver drugs, cytokines, and growth factors as carriers, which will greatly accelerate wound healing. Wichterle et al., reported the first case of hydrophilic gel in 1960, the results of the application of hydrogel in wound healing have become increasingly abundant. Current conventional approaches to wound treatment including the application of different types of dressings, electrical stimulation therapy, skin grafting, and negative pressure wound therapy (NPWT) have proven beneficial, but they also have certain limitations. In cases such as deep burns or diabetes, the wound’s self-healing ability is limited, and supportive methods are needed to accelerate and protect the wound healing process. Although human skin can heal itself after injury, this is limited to superficial wounds. Therefore, skin wound healing is an important step in the survival to complete wound closure. Finally, we believe that the combination of AI and optical imaging technology in the development and efficacy monitoring of hydrogels will be a promising research direction in the future.Īs the largest organ system in the human body, the skin plays a vital role in maintaining the body’s physiological stability, protecting the skin from external stimuli, preventing infection, and maintaining fluid balance. Furthermore, we further discuss the superiority and potential of current artificial intelligence (AI) technology in dermatological diagnosis, and analyze the application status of hydrogel in skin wound treatment. The research results of the application of non-invasive optical techniques such as diffuse reflectance spectroscopy (DRS) and optical coherence tomography (OCT) in scar identification, skin bruising, and skin and vascular structure identification are reviewed. Moreover, we discuss the potential of non-invasive optical imaging techniques in the assessment of cutaneous wound healing. In this chapter, we focus on the materials and methods of hydrogel preparation, and discuss the properties that hydrogels should possess for the treatment of wounds. Recently hydrogels and the treatment of skin wounds based on hydrogel dressings have become one of the research hotspots in the field of skin trauma.
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